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  • Writer's picturePiper Harris

30 Day Review: Peptides and Mental Wellbeing

I recently ventured into peptide therapy, an exploration aimed at deepening my understanding of how these intricate helpers can support our mental health. This 30-day journey, in partnership with RegenMD Wellness, is about my personal experience but shedding light on alternative paths that might pave the way for healing and balance for those struggling with mental health issues such as anxiety, depression, and even addiction and personality disorders.

Join me; let's embark on this discovery with open hearts and minds, ready to learn and grow.

Brain and Gut

The intricate gut-brain connection underscores the pivotal role of gut health in maintaining positive mental health, highlighting how our emotional state is deeply entwined with the health of our gastrointestinal system. As detailed in a Harvard Health publication, the gastrointestinal tract is highly sensitive to emotions such as anger, anxiety, and sadness, which can trigger noticeable symptoms in the gut. This bidirectional communication pathway means that a troubled gut can signal distress to the brain and vice versa, thereby linking psychological stressors directly to gastrointestinal distress. The phenomena become particularly pronounced in the context of functional GI disorders, where the absence of an apparent physical cause points towards the significant impact of stress and emotional wellness on gut health.

Incorporating the peptide BPC157 orally, I've noticed a noteworthy improvement in my gut health, significantly sustaining my mental positivity. BPC157 is reputed for its potent gut-healing properties, promoting the repair and healthy function of the GI tract, which plays a crucial role in enhancing the gut-brain interaction. This aligns with observations from the same Harvard Health publication, suggesting that addressing functional GI conditions with treatments that also focus on stress reduction, anxiety, or depression could lead to better outcomes. Hence, by improving my gut health through the use of BPC157, I'm addressing potential GI distress and fostering an environment conducive to enhanced mental well-being, leveraging the interconnectedness of gut health and mental health to maintain an overall positive outlook.

Human Growth Hormone and Cognition

The use of the peptide Sermorelin, which functions by promoting the natural release of growth hormone (HGH) in the body, has proven to be a crucial element in enhancing my overall mental health through its profound impact on sleep. Historically, sleep had been an elusive cornerstone of my health, with quality rest remaining just out of reach for much of my life.

However, since incorporating Sermorelin into my routine, the most noticeable and transformative effect has been on my ability to achieve deep, restorative sleep. This improvement is not just anecdotal but is reflected in the broader scientific community's findings, such as those highlighted in a study published by JAMA Neurology. The research delineates the beneficial role of growth hormone-releasing hormone (GHRH), akin to the mechanism activated by Sermorelin, in improving cognitive function through its effect on sleep.

The interplay between enhanced sleep and cognitive performance cannot be overstated.

In the JAMA Neurology article, researchers observed favorable effects on cognition in older adults following a controlled trial of GHRH, indicating that increased HGH levels can significantly bolster cognitive functions. This insight has been mirrored in my experience, where the deep, quality sleep facilitated by Sermorelin seems to have laid the groundwork for improved mental resilience and cognitive clarity. I believe the ability to navigate life's difficulties and distress with greater agility is largely attributable to the more profound, rejuvenating sleep I've been getting. This enhanced sleep linked to Sermorelin represents a pivotal breakthrough in my longstanding struggle with sleep issues. It emphasizes the peptide's potential to promote mental well-being through the fundamental, often understated pathway of sleep optimization.

Personal Thoughts and Warnings

In my journey over the last 30 days, embarking on a thoughtful exploration with BPC157 and Sermorelin, I sought not just answers but understanding. I meticulously tracked my mental well-being using well-established measures such as the WHO-5, PHQ-9, and GAD-7, searching for shifts and nuances that could offer deeper insight. The process was revealing - a testament to the power of self-reflection and the potential for transformation. While the numbers provided a framework, the true value lay in the increased awareness and connection to my mental landscape. This exploration is a reminder of our perpetual capacity for growth and change, and it underscores the importance of holistic approaches in our quest for emotional health and balance. It's a path that many might find daunting, yet with the right support and understanding, it's one that can lead to profound discoveries about our resilience and potential for healing.

While Sermorelin has garnered much attention for its aesthetic benefits, such as improved skin quality and lean muscle mass, it is essential to approach this aspect with a gentle self-awareness, especially for individuals who, like me, have a history of body dysmorphia. The transformation of one's external appearance can be uplifting; it feels empowering to see the reflection in the mirror that resonates with how we feel inside. However, my journey has taught me the importance of not fixating solely on the external. With body dysmorphia, the struggle is profound, often warping self-perception and creating a preoccupation with imagined flaws. It has been vital to consciously ground my sense of self-worth beyond external changes, even if those changes are appreciated and celebrated.

In considering the referral of clients to peptides like Sermorelin, it weighs on me—the concern that this might be perceived as just another answer in a pill form, a quick fix to more deep-seated issues. I firmly believe, and my professional practice is grounded in the understanding that mental well-being is multifaceted; it's not something that can or should be addressed by psychotropic medication or peptides alone. These treatments may play a role in a comprehensive care approach, but they are certainly not the entirety of the journey to mental health. 

I advocate for a path that includes developing robust coping skills, emotional resilience, and the tools necessary for navigating life's challenges. It's about embracing our emotions, not avoiding or denying them, identifying problem behaviors, and reframing our cognitions and filters of life for the holistic betterment of self. 

Each of us has the potential to grow and heal; true transformation happens with the aid and integration of compassionate therapy and personalized well-being strategies, reinforcing our innate strength and wisdom.

Interested in peptides and how they can bolster your mental wellbeing? Contact Regen today!


Are you tired of hearing about a holistic approach with other therapists only to find that it involves little more than counseling? Untangled Mind works to develop relationships with individuals and businesses that provide for many areas of your life. Each provider has a personal relationship with Piper, ensuring ethical and holistic care. Ready to learn more and step into a different kind of counseling experience? Call now to schedule a complimentary consultation. 770-317-1126

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